Arylsulphonyl ureas containing heterocyclic acylamino groups

ABSTRACT

Blood sugar lowering compounds useful as oral anti-diabetics are provided. The compounds have low toxicity and are well tolerated. They are arylsulphonyl ureas having heterocyclic acylamino groups such as N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)benzene-sulphonyl)-N&#39;&#39;-cyclohexyl-urea and its congeners and analogs administrable in tablets or capsules containing for example 1 mg of active agent. The compounds can be prepared in several ways such as by reacting an appropriate amine or amine salt with a heterocyclic acylamino group-containing arylsulphonamide derivative or corresponding arylsulphonylisocyanate. The substituents on the benzene ring are preferably para to one another but may be in the ortho and meta positions to each other. The reactions can be carried out with or without a solvent or diluent and are exothermic or heated at elevated temperature.

o United States Patent [111 3,718,660 Plumpe et Feb. 27, 1973 [56] References Cited CONTAINING HETEROCYCLIC UNITED STATES PATENTS ACYLAMINO GROUPS 3,400,122 9/1968 Albrecht et al ..260/239.9 [7 5] Inventors: Hans Plumpe; Walter Puls, WuppertaLEIb -f M Germany Primary ExaminerAlex Mazel v Assistant ExaminerR. V. Rush [73] Asstgnee: Farbenfabriken Bayer Aktien- Atwmey J b & J b

gesellschaft, Leverkusen, Germany 22 Filed: Oct. 28, 1968 [57] ABSTRACT Blood su ar lowering com ounds useful as oral anti- [211 Appl' 7713l8 diabetics are provided. The compounds have low toxicity and are well tolerated. They are arylsulphonyl [30] F i A li ti n p i i D ureas having heterocyclic acylamino groups such as N- [4-(B-[3-methylisoxazolyl-( 5 )-carboxamido]-ethyl)- NOV. 2, Germany benzene-sulphonyl] N' cyclohexyl urea and conl geners and analogs administrable in tablets or capsules [52] US. Cl ..260/307 D, 260/247.l, 260/268 BC, containing for example 1 mg of active agent. The 260/268 C, 260/293.54, 260/293.58, compounds can be prepared in several ways such as 260/293.67, 260/302 F, 260/302 H, 260/302 by reacting an appropriate amine or amine salt with a A, 260/307 H, 260/310 R, 424/248, 424/267, heterocyclic acylamino group-Containing aryl- 424/270, 424/272 424/273 sulphonamide derivative or corresponding a'ryl- 51 lnLCl. ..C07d 85/22 sulphonylisocyanate- The substiwems on the benzene [581' Field of Search ..t ..260/307 n, ring are P f P (me h but may be 2471 2 3 BC263 C 260/29354, 29358, the ortho and meta positions to each other. The reac- 29167, 307 D tions can be carried out with or without a solvent or diluent and are exothermic or heated at elevated temperature. V

23 Claims, No Drawings ARYLSULPHONYL UREAS CONTAINING HETEROCYCLIC ACYLAMINO GROUPS It is known that arylsulphonyl urea derivatives possess a blood sugar depressing action. The compound N- (4-methyl benzene-sulphonyD-N-butyl urea (tolbutamide), in particular, has attained great importance as a pharmaceutical agent dueto its blood sugar depressing properties while simultaneously having good compatibility. I

The, present invention relates to new heterocyclic acylamino-containing sulphonyl ureas of the formula:

' R and R" are each individually hydrogen, halogen atoms or alkyl, or aryl, aralkyl or cycloalkyl radieals which are unsubstituted or substituted by halogen, alkyl, alkoxy or trifluoromethyl,

R' and R"" are each hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, phenoxyalkyl, unsubstituted or alkyl-substituted cycloalkyl, cycloalkylalkyl, bicycloalkyl, bicycloalkylalkyl, tricycloalkyl, tricycloalkylalkyl, tetracycloalkyl or tetracycloalkylalkyl, aryl or aralkyl unsubstituted or substituted by halogen, alkyl, alkoxy or trifluoromethyl, or together, with the adjacent nitrogen atom, a monocyclic or polycyclic radical having one or more hetero atoms and which are unsubstituted or alkyl-substituted;

X is oxygen, sulphur, nitrogen substituted by hydrogen, or alkyl, aryl or aralkyl which is unsubstituted or substituted by halogen, alkyl, alkoxy or trifluoromethyl;

Y is a direct bond, a straight chain or branched alkylene radical of one to eight carbon atoms, and

n is a number between and 4; the substituents on thebenzene ring stand in the ortho-, meta-, but

preferably in the para-position towards one another.

These new compounds, either by themselves or in the form of their alkali metal or alkaline earth metal salts, possess a strong blood sugar depressing action which is superior to that of tolbutamide.

They are therefore intended to be used as pharmaceutical, agents to be administered per us for the treatment of diabetes.

The new arylsulphonyl urea derivatives are prepared:

a. by reacting an amine of the formula HNR"R"" in which R'" and R"" have the same meaning as above, optionally also in the form of their salts, with a heterocyclie acylaniino group-containing arylsulphonamide derivative of the formula:

in which in which A is, for example, halogen, azido, alkoxy, aryloxy, al-

kylmercapto or arylmercapto group or substituted or unsubstituted amino, cyclic amino or acylamine; or b. by reacting an arylsulphonamide of the formula:

i H -1 (CH-z) m-C-N-Y SOrNI-I in which R, R, R", X, Y and n have the same meaning as above, by itself or in the form of an alkali metal salt with an amine derivative of the formula: B CO NR"'R"" or, if R"-' is hydrogen, with an isocyanate 0 C N R"", in which B is a radical which reacts in the course of the reaction with a hydrogen atom of the sulphonamide group or the alkali metal atom M of the corresponding sulphonamide alkali metal salt with the elimination of H8 or MB; B is, for example, halogen, azido, alkoxy, aryloxy, alkylmercapto or arylmercapto, substituted or unsubstituted amino, cyclic amino or acylamino; or g c. by reacting an arylsulphonyl halide of the formula:

smashes N in which R, R, R", R, R"", X, Y and n have the same meaning as above, into the desired products of the process, in the case of thioureas (Z SH) by oxidative hydrolysis, in the case of arylsulphonyl guanidines (Z Nl-l arylsulphonyl- O-alkyl-isoureas (Z 0 alkyl), arylsulphonyl-S- alkyl-isothioureas (Z S alkyl), or arylsulphonylisourea chlorides (Z chlorine) by an acid or alkaline hydrolysis; or

e. by acylating an amino-(alkyl)-benzene-sulphonyl urea of the formula:

0 R!!! l l H-NY 0zNHd:N

' IIIII in which Y, R, R and R" have the same meaning as above,

with a carboxylic acid or derivative:

R, R", X and n have the same meaning as above, and R""' is a group which reacts with the hydrogen on the amino group of its aforementioned reaction component with the elimination of R"" H; in this context R""' is hydroxy, alkoxy or aryloxy or a halogen atom, preferably chlorine; or

f. by oxidizing a benzene-sulphenyl urea (m 0) or a benzene-sulphinyl urea (m l of the formula:

R, R', R", R, R"", X and Y and n have the same 45 meaning as above;

g. by reacting a sodium salt of an N-bromoamide:

with a formamide:

in which R, R, R", R', R"", X, Y and n have the same meaning as above; or h. by hydrolyzing a parabanic acid derivative of the 15 in which R, R, R", R, X, Y and n have the same meaning as above;

i. by allowing water to react with an N-sulphonylcarbonyl-diimide of the formula:

in which R, R, R", R', X, Y and n have the same meaning as above.

Each of the end products of the methods (h) and (i) has hydrogen as the substituent R"".

Carboxylic acids on which the heterocyclic acyl radical in the end products claimed are based, are the following, for example: isoxazole-(5)-carboxylic acid, 3-methylisoxazole-(5 carboxylic acid, 5-methyl-isoxazole-(3)-carboxylic acid, 5-methyl-3-phenylisoxazole-(4)-carboxylic acid, 3-(2',5 -dichlorophenyl)-5-methyl-isoxazole-(4)- carboxylic acid, 3,5-dimethyl-isoxazole-(4)-carboxylic acid, isoxazole-(3)-carboxylic acid, isoxazole-(4)-carboxylic acid, 3-methyl-isoxazole-(4)-carboxylic acid, 5-methylisoxazole-(4)-carboxylic acid, 4,5- dimethylisoxazole-(3 )-carboxylic acid, S-hexyl-isoxazole-( 3 )-carboxylic acid, 5-octylisoxazole-(3 )-carboxylic acid, 5-phenylisoxazole-(3)-carboxylic acid, 5- tert.-butyl-3-phenyl-isoxazole-(4)-carboxylic acid, 3,5- diphenyl-isoxazole-(4)-carboxylic acid, 3-ethyl-5- methylisoxazole-(4)-carboxylic acid, 5-methyl-3-phenylisoxazole-(4)- carboxylic acid, 3-phenylisoxazole- (4)-carboxylic acid, 5-phenylisoxazole-(4)-carboxylic acid, 4-chloro-3-methylisoxazole-(5)-carboxylic acid, 4-phenyl-isoxazole-( 5 )-carboxylic acid, 3,4- tetramethylene-isoxazole-(5)-carboxylic acid, 4,5- tetramethyleneisoxazole-(3)-carboxylic acid, fl-isoxazolyl-(5)-propionic acid, 3,5-dimethyl-isoxazolyl-(4)- acetic acid, 4-phenyl-isothiazole-(3)-carboxylic acid, 5-phenyl-isothiazole-(3)-carboxylic acid, isothiazole- (4)-carboxylic acid, 3-methyl-isothiazole-(4)-carboxylic acid, 3,5-dimethyl-isothiazole-(4)-carboxylic acid, 3-

methyl-S-benzylisothiazole-( 4 )-carboxylic acid 3- methyl-5-ethyl-isothiazole-( 4 )-carboxylic acid, 3- methyl-S-propylisothiazole-(4)-carboxylic acid, 3- ethyl-S -phenyl-isothiazole-( 4 )-carboxylic acid,

isothiazole-(S )-carboxylic acid, 3-methylisothiazole- (5 )-carboxylic acid, 4-methyl-isothiazole-(5 )-carboxylic acid.

' bicyclo[2,2,l l-heptyl-(2)-methylamine,

methyl-piperidine-(4),

Also, pyrazole-(3)-carboxylic acid, pyrazole-(4)-carboxylic'acid, 1-methyl-pyrazole-(5)-carboxylic acid, 4- methylpyrazole-(S)-carboxylic acid, 3-methylpyrazole- (4) -carboxylic acid, 3-methylpyrazole-(5)-carboxylic acid, 1-phenylpyrazole-(3)-carboxylic acid, l-phenylpyrazole-(4)-carboxylic acid, 1-phenylpyrazole-(5)- carboxylic acid, 4-phenylpyrazole-(3)-carboxylic acid, 3-phenylpyrazole-(4)-carboxylic acid, 3-phenylpyrazole-( 5 )-carboxylic acid, 3-methyl-l -phenylpyrazole'-(4)-carboxylic acid, S-methyl-l-phenylpyrazole- (4 )-carboxylic acid, 5 -methyl-1-phenylpyrazole-( 3 )-carboxylic acid, 3-methyl-l -phenylpyrazole-( 5 )-carboxylic acid, 1 -m ethyl-5 -phenylpyrazole-( 3 )-carboxylic acid, l-m ethyl-5 -phenylpyrazole-( 5 )-carboxylic acid, 4-methyl-3 -phenylpyrazole-( 5 )-carboxylic acid, 3 -methyl-5 -phenyl- 4-(q-aminoethyl)-benzenesulphonamide, 4-(paminoethyl)-henzene-sulphonamide, 4-(aaminopropyl )-benzene-sulphonamide, 4-( B- aminopropyl)-benzenesulphonamide, 4-(yaminopropyl-sulphonamide), 4-(a-a i dimethylmethyl)-benzene-sulphonamide, 4-methylaminobenzenesulphonamide, and similar compounds in the form of their bases or as salts with acids.

As amines on. which the group NR"'R"" in the products of the present invention are based the follow ing may be used, for example: methylamine, ethylamine, propylamine, isopropylamine, butylamine and their higher, straight chain or branched homologues, particularly those containing up to twelve carbon atoms; furthermore aniline, benzylamine, aphenethylamine, cyclohexylmethylamine, bicyclo- [2,2,1 ]-heptyl-(2)- methylamine, tetracyclo- (2,2,1 ,0'-2--" )-nonyl-( 8 )-methylamine,cyclopentylamine, cyclohexylamine, cycloheptylamine, bicyclo- [2,2,1]-heptyl-(2)-amine, nortr icyclylamine, adamantyl-amine, adamantyl-methylamine as well as their alkyl substitution products, such as, e.g., 4-methyl-cyclohexylamine, 2,6-dirnethylcyclohexylamine, 2-methyla[bicyclo-[ 2,2,1)-heptyl-(2)]-ethylamine, 2a, 4,5,6,7,7a-hexahydro-4,7-methano-indanyl 1 )-amine,fenchylamine or bornylamine; also methoxy-propylamine, phenoxyethylamine, tetrahydrofurfuryl-rnethylamine, 1- methyl-tetrahydrofurfuryl-methylamine; furthermore unsaturated amines, such as allylamine or cyclohexenl )-yl-ethylamine; furthermore dimethylamine, diethylamine and homologous dialkylamines with straight chain or branched, saturated or unsaturated alkyl radicals containing altogether 12 carbon atoms, N-methylbenzylamine, N-methyl-cyclohexylamine, N- methyl-cyclohexylmethylamine, pyrrolidine, piperidine, morpholine, hexamethyleneimine, 4-

3-aza-bicyelo-[3,2,1 ]-octane, 6-azabicyclo-[3,2,l l-oc- 3-azabicyclo-[3,2,01-heptane,

tane,3-azabicyclo-[3,2,2]-nonane, 3-azabicyclo-[3,3,1 ]-nonane, 2-azabicyclo-[2,2,2]-octane, nortropane, granatanine and their alkyl-substitution products camphidine, 4,7-endocyclo-propylene-A -hexahydroisoindole, 4,7-endocyclobutenylene-A hexahydroisoindole, 4,7-endocyclobutylene-octahydroisoindole.

Dependent on the method employed, the amines are used by themselves or in the form of their derivatives, such as carbamic acid chlorides, carbamic acid esters or carbamic acid azides.

The reactions are carried out without or in suitable solvents or diluents, and the reaction itself proceeds, depending upon the reactivity of the components, exothermically or its course has to be forced or promoted by applying elevated temperatures. The end products can, moreover, be converted into therapeutically applicable non-toxic salts.

Products of the present invention which contain one or more optically active carbon atoms can be obtained, not only in the form of their racemates, but also in their optically active forms by either using for their produc tion from the start an appropriate, optically active bicyclic amino compound or, alternatively, by subjecting racemic intermediate stages or end products to a racemate splitting.

EXAMPLE 1 (a) g (0.55 mol) of 3-Methyl-isoxazole-(5)-carboxylic acid chloride were introduced in portions into 118 g (0.52 mol) of 4-B-aminoethylbenzene-sulphonamide hydrochloric in 500 ml of pyridine at a temperature between 0 and 20 C. The mixture was stirred at room temperature for one hour and at 60 C. a further hour, then poured into ice-water, the precipitate filtered off with suction, washed with water and recrystallized from ethanol with the addition of activated charcoal, There were obtained 1 13g (7lpercent of theory) of 4-[B-[3-methylisoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonamide in the form of colorless crystals of m.p. 2 19 220 C. (Kofler heating block).

(b) 7.3 g (0.024 mol) of 4-(B-[3-methylisoxazolyl- (5)-carboxamido]-ethyl)-benzene-sulphonamide were stirred under reflux for 30 minutes in ml of methyl ethyl ketone with 4.1 g (0.05 mol) of powdered potassium carbonate; 4.4 g (0.035 mol) of cyclohexyl-isocyanate were then added dropwise at 20 C. while stirring, the mixture was stirred at room temperature for 30 minutes and under reflux for 2 hours; after cooling the mixture, the precipitate was filtered off with suction, dissolved in water, the solution filtered and acidified with hydrochloric acid. The precipitated product was filtered off with suction, washed with water and dried. There were thus obtained 8.5 g (82 percent of theory) of N-[4-(B-[3-methyl-isoxazolyl-(5 )-carboxamido]-ethyl)-benzene-sulphonyl ]-N-'- cyclohexyl-urea in the form of a colorless, finely crystalline powder of m.p. 206 C. (Kofler heating block).

EXAMPLE 2 By analogy to Example 1(b) there are obtained from 4-( B-[ 3 -methylisoxazolyl-( 5 )-carboxamido ]-ethyl)- benzenesulphonamide and propylisocyanate, the compound N-4-(B-[3- methylisoxazolyl-(S)-carboxamido]- ethyl)-benzene-sulphonyl]-N'-propyl urea of m.p. 214 C.;

and butylisocyanate, the compound N-[4-(B[3- methylisoxazlyl-( )-carboxamido ]-ethyl)-benzenesulphonyl]-N'-butyl urea of m.p. 195 to 197C.;

and 2,5-endomethylene-cyclohexyl-methylisocyanate, the compound N-[4-(B-[3-methylisoxazolyl-(5)-carboxamido]-ethyl)-benzene-sulphonyll-N'-(2,5-endomethylene-cyc1ohexyl-methyl)-urea of m.p. 203 C.; and 1-methyl-2,5-endomethylene-cyclohexylmethylisocyanate the compound N-[4-(B-[ 3- methylisoxazolyl-(S )-carboxamido]-ethyl)-benzenesulphonyl]-N -(1-methyl-2,4-endomethylenecyclohexylmethyl)-urea of m.p. 199 C.;

and nortricyclylisocyanate, the compound N-[4-(B-[3- methyl-isoxazolyl-( 5 )-carboxamido]-ethyl)-benzenesulphonyl]-N'nortricyclyl-urea of m.p. 181 C.;

and 4-methylcyclohexylisocyanate, the compound N- [4-( B-[3-methylisoxazolyl-( 5 )-carboxamido]-ethyl benzene-sulphonyl1-N'-(4-methylcyclohexyl)-urea of m.p. 220 C.;

and phenylisocyanate, the compound N-[4-(B-[3- methylisoxazolyl-(S)-carboxamido]-ethyl)-benzenesulphonyl]-N '-phenyl-urea of m.p. 200 C.;

and allyl-isocyanate, the compound N-[4-(B-[3- methylisoxazolyl-(S )-carboxamido]-ethyl)-benzenesulphonyl]-N'-allyl-urea of m.p. 214 C.; and 2,6- dimethylcyclohexylisocyanate, the compound N-[4-(B- [3-methylisoxazolyl-( 5 )-carboxamido]-ethyl)- benzene-sulphonyll-N'-(2,6-dimethylcyclohexyl)-urea of m.p. 225 to 232 C.; and cyclododecyl-isocyanate, the compound N-[4-(B-[3methylisoxazolyl-(5)-carboxamido]-ethyl)-benzene-sulphonyl]-N'- cyclododecyl-urea of m.p. 224 C.;

and 1,6,6-trimethyl-2,5-endomethylene-cyclohexylisocyanate, the compound N-[4-[3-methylisoxazolyl- (5 )-carboxamido]-ethyl )-benzene-s'ulphonyl]-N (1,6,6-trimethyl-2,5-endomethylene-cyclohexyl)-urea ofm.p. 110 C.

EXAMPLE 3 By analogy to Example 1 there are obtained from 3- phenyl-S-methyl-isoxazole-( 5 )-carboxylic acid chloride and 4-(B-aminoethyl)-benzene-sulphonamide hydrochloride, the 4-(B-[ 3-phenyl-5-methy1-isoxazolyl- (4)-carboxamido]-ethyl)-benzene-sulphonamide in the form of colorless crystals of m.p. 216 C.; from dimethyl formamide/water and therefrom with cyclohexyl-isocyanate, the N-[4-(B-[3-phenyl-5- methylisoxazolyl-(4)-carboxamido]-ethyl)-benzenesulphonyl]-N'-cyclohexyl urea of m.p. 205 C. (from methanol).

ln corresponding manner there are obtained from 3- (2,6-dichlorophenyl)-5-methyl-isoxazolyl-(4)-carboxylic acid chloride and 4-(B-aminoethyl)-benzenesulphonamide hydrochloride, the compound 4-(18-[3- (2',6'-dichlorophenyl)-5-methyl-isoxazolyl-(4)-carboxamido]-ethyl)-benzen3-sulphonamide of m.p. 194 C. (from dimethyl formamide/water) and therefrom with cyclohexyl-isocyanate, the N-[4-( -[3-(2,6'- dichlorophenyl)-5-methyl-isoxazolyl-(4)-carboxamido)-ethyl]-benzene-sulphonyl]-N'-cyclohexyl urea ofm.p. 218 C.

EXAMPLE 4 By analogy to Example l there are obtained from 5- methyl-isoxazole-(3)-carboxylic acid chloride and 4- (B-aminoethyl)-benzene-sulphonamide hydrochloride,

the 4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]- ethyl)-benzene'sulphonamido in the form of colorless crystals of m.p. 213 to 214 C. (from dimethyl formamide/water) and therefrom with cyclohexyl-isocyanate, the N-[4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl)-benzene-su1phonyl]-N'-cyclohexyl urea in the form of a colorless, finely crystalline powder of m.p. 198 C.

EXAMPLE 5 By analogy to Example 1 there are obtained form 3- methyl-isoxazole-(S)-carboxylic acid chloride and 4- aminobenzene-sulphonamide, the 4-[3-methyl-isoxazolyl-(S)-carboxamido]-benzene-sulphonamide in the form of colorless crystals of m.p. 249 C., and therefrom with cyclohexyl-isocyanate the compound N-( 4-[ 3-methyl-isoxazolyl-( 5 )-carboxamido -benzenesulphonyl)-N'-cyclohexyl urea in the form of a color less powder of m.p. 207 C.

EXAMPLE 6 By analogy to Example 1 there are obtained from 3- methyl-isoxazole-(S)-carboxylic acid chloride and 4- aminomethyl-benzene-sulphonamide, the 4-[3-methylisoxazolyl-(S)-carboxamido-methyl]-benzenesulphonamide in the form of colorless crystals of m.p. 210 to 211 C. and therefrom with cyclohexyl-isocyanate the N-(4-[3-methyl-isoxazolyl-(5)-carboxamide-methyl]-benzene-sulphonyl)-N'-cyclohexyl urea in the form ofa colorless powder of m.p. C.

EXAMPLE 7 EXAMPLE 8 By analogy to Example 1 there are obtained from 3- methyl-isoxazole-(S)-carboxylic acid chloride and 4- (a-aminoethyl)-benzene-sulphonamide, the compound 4-(a-[a93-methyl-isoxazolyl-(5 )-carboxamido]-ethyl)- benzene-sulphonamide in the form of colorless crystals of m .p. 172 C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(a-[3-methyl-isoxazolyl- )-carboxamido]-ethyl)-benzene-sulphonyl]-N- cyclohexyl-urea in the form of colorless crystals of m.p. 190 C.

EXAMPLE 9 By analogy to Example 1 there are obtained from 5 methyl-isoxazole-(3)-carboxylic acid chloride and 4- (a-aminoethyl)-benzene-sulphonamide, the compound 4-(a-[a95 -methyl-isoxazolyl-( 3 )-carboxamido]-ethyl benzene-sulphonamide in the form of colorless crystals of m.p. 178 C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(a-[S-methyl-isoxazolyl- (3)-carboxamido]-ethyl)-benzene-sulphonyl]-N'- cyclohexyl-urea in the form of a colorless crystalline powder ofm.p. 173 to 174 C.

In corresponding manner there are obtained with 4- methyl-cyclohexyl-isocyanate, the compound N-[4-(a- [5-methyl-isoxazolyl-( 3 )-carboxamido]-ethyl)- benzene-sulphonyl]N'-(4-methyl-cyclohexyl)-urea in the form of a colorless finely crystalline powder of m.p. 192 C.

EXAMPLE By analogy to Example 1 there are obtained from 1- phenylpyrazole-4-carboxylic acid chloride hydrochloride (prepared from the corresponding acid and thionyl chloride) and 4-(B-aminoethyl)-benzenesulphonamide, the compound 4-(B-[1-phenylpyrazolyl- (4)-carboxamido]-ethyl)-benzene-sulphonamide in the form of a colorless crystalline powder of m.p. 240 C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(B-[l-phenylpyrazolyl-(4)-carboxamido]- ethyl)-benzene-sulphonyl]-N-cyclohexyl-urea in the form of a colorless crystal powder of m.p. 210 to 214 C.

EXAMPLE 1 l a. 92.8 g (0.3 mol) of 4-(B-[3-methyl-isoxazolyl-(5)- carboxamido]-ethyl)-benzene-sulphonamide are heated under reflux for 40 minutes while stirring in 1.5 liter of methyl ethyl ketone with 82.8 g (0.6 mol) of powdered potassium carbonate. After cooling the mixture to room temperature, 47.3 g (0.5 mol) of chloroformic acid methyl ester are added dropwise, the mixture is stirred at room temperature for minutes and under reflux for 4 hours, and it is filtered off with suction and washed with methyl ethyl ketone. The residue is dissolved in water, the solution clarified with activated charcoal and the filtrate acidified with hydrochloric acid. The precipitate is filtered off with suction, washed with water and dried. There are obtained 85.6 g (77 percent of theory) of N-[4-(fl-[3- methyl-isoxazo1yl-( 5 )-carboxamidol-ethyl )-benzenesulphonyl]-methyl urethane in the form of a colorless, finely crystalline powder of m.p. 184 C.

b. 7.3 g (0.02 mol) of this compound are dissolved in 150 ml of methanol, 2.5 g (0.022 mol) of cyclopentylamine are added and the methanol is distilled off, finally under reduced pressure. The residue is finally heated at 1 10 to 120 C. for 30 minutes, which solidifies as a solid mass and is recrystallized from methanol. There are obtained 5.4 g (70 percent of theory) of N- [4-(B-l3-methyl-isoxazolyl-( 5 )-carboxamido]-ethyl benzene-sulphonyl)-N'-cyclopentyl-urea in the form of colorless crystals of m.p. 227 C.

EXAMPLE 12 a. By analogy to Example 11(a) there are obtained from 4(B[5-methyl-isoxazolyl-(3)-carboxamido]- ethyl)-benzene-sulphonamide and chloroformic acid methyl ester in a yield of 69percent the compound N-- [4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-methyl-urethane in the form of colorless crystals of m.p. 173 C.

b. From the sulphonyl urethane described above and cyclopentylamine there are obtained, in analogy to the method described in Example 11(b), in a yield of 52 percent, the compound N-[4-(B-[S-methyl-isoxazolyl- (3 )carboxamido]-ethyl )-benzene-sulphonyl]-N cyclopentyl-urea in the form of colorless crystals of m.p. 210 C.

EXAMPLE 13 By analogy to Example 11(b) there are obtained from N-[4 (B-[3-methyl-isoxazolyl-(5)-carboxamido]- ethyl)-benzene-sulphonyl]-methyl-urethane and benzylamine, the compound N-[4-(B-[3-methylisoxazolyl-( 5 )-carboxamido]-ethyl )-benzene-sulphonyl]- N'-benzyl-urea of m.p. 180 C.; B-(cyclohexene-l-yl)-ethylamine, the compound N-[4- (B-[ 3-methyl-isoxazolyl-( 5 )-carboxamido ]-ethyl benzene-sulphonyll-N'-[B-(cyclohexene-1-yl)-ethyl]- urea of m.p. to 194 C.; and cyclooctylamine, the compound N-[4-(B-(3-methylisoxazo1yl(5)-carboxamido]-ethyl)-benzene-sulphonyl]-N'-cyclooctyl-urea ofm.p. 174C.; and hexahydrobenzylamine, the compound N-[4-(B- [3-methylisoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-hexahydrobenzyl-urea of m.p. 190 to 192C.; and 4,7-endocyclobutylene-( l ,2' )-octahydroisoindole; the compound N-[4-(B-[3-methylisoxazolyl-(5)- carboxamido]-ethyl)-benzene-sulphonamidocarbonyl]-4,7-endocyclobutylene-(1,2')-octahydro-isoindo1e of m.p. 145C.; and 1-phenyl-cyclohexylamine, the compound N-[4-(B 3 methylisoxazolyl 5 (5) carboxamido] ethyl) benzene-sulphonyll-N 1-phenyl-cyclohexyl)-urea of m.p.181183C.; and cycloheptylamine, the compound N-[4-( -[3' methylisoxazolyl-( 5 )-carboxamido]-ethyl )-benzenesulphonyl1-N-cycloheptyl urea of m.p. 199 C.

EXAMPLE 14 By analogy to Example 11(b) there are obtained from N-[4-(B-I5-methylisoxazolyl-(3)-carboxamido]- ethyl)-benzene-sulphonyl]-methyl-urethane and hexahydrobenzylamine, the compound N-[4-(B-[5- methylisoxazolyl( 3 )-carboxamido]-ethyl )-benzenesulphonyl1-N-hexahydrobenzy1-urea of m.p. 140 C.; and B-(cyclohexene-l -yl)-ethylamine, the compound N- [4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-[B-(cyclohexene-l-yl)-ethyl]- urea of m.p. 196 to 198 C.; and l-phenylcyclohexylamine, the compound N-[4-(B-[5-methy1-isoxazolyl- (3 )-carboxamido]ethyl)-benzene-sulphonyl]-N 1- phenylcyclohexyl)-urea of m.p. 193 C.; and cycloheptylamine, the compound N-[4-(B-[5- methylisoxazolyl-( 3 )-carboxamido]-ethyl)-benzenesulphonyl]-N-cycloheptyl-urea of m.p. 187 C.,

and cyclooctylamine, the compound N-[4-(B-[5- methylisoxazolyl-( 3 )-carboxamido]-ethyl)-benzenesulphonyll-N '-cyclooctyl-urea of m.p. 173 C.;

and 4,7-endocyclobutylene-(1',2)-octahydroisoindole, the compound N [4-(B-[5-methylisoxazolyl-(3)- carboxamido]-ethy1-benzene-sulphonamidocarbonyl]- 4,7-endocyclobutylene-(l',2')- octahydroisoindole of m.p. 198 C.;

and hexahydro-B-phenethylamine, the compound N- [4-(B-[5-methylisoxazolyl-( 3 )-carboxamido]-ethyl)- benzene-sulphonyl1-N'-(hexahydro-B-phenethyl)-urea of m.p. 190 C.;

and pyrrolidine, the compound N-[4-(B-[5-methylisoxazolyl-( 3 )-carboxamido -ethyl )-benzenesulphonamidocarbonyl]-pyrrolidine of m.p. 235 C.; and piperidine, the compound N-[4-(B-[5-methy1isoxazoly1-(3 )-carboxamido]-ethyl)-benzenesulphonamidocarbonyl]-piperidine of m.p. 183 C.; and hexamethyleneimine, the compound N-[4-(B-[5- methylisoxazolyl-(3)-carboxamido]-ethyl)-benzenesulphonamidocarbonyl]-hexamethyleneimine of m.p. 186 C.;

and morpholine, the compound N-[4-(B-[5- methylisoxazolyl-(3)-carboxamido]-ethyl)-benzenesulphoncarbonyl]-morpholine of m.p. 170 C.;

and N-methylpiperazine, the compound N-methyl-N- [4-(13-[5 -methylisoxazo1yl-(3 )-carboxamido]-ethyl)- benzene-sulphonamidocarbonyl]-piperazine of m.p. 201 C.;

and 2-azabicyclo[2,2,21octane, the compound N-[4-(B methylisoxazolyl (3) carboxamido] ethyl) benzene-sulphonamidocarbonyl]-2-azabicyclo[3,2,2] octane ofm.p. 207 210 C.;

and 3-azabicyclo[3,2,2]nonane, the compound N-{4- (B-[5-methy1isoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonamidocarbonyl]-3-azabicyclo[3,2,2] nonone of m.p. 175 C.; and camphidine, the compound N-[4-(B-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)-benzene-sulphonamidocarbonyl]-camphidine ofm.p. 179 C.

EXAMPLE 15.5 g (0.05 mol) of 4-B-(5-Methy1isoxazolyl-(3)- carboxamido]-ethyl-benzene-sulphonamide are stirred at 80 C. for 8 hours in 400 ml of ethoxy ethanol with 6.2 g (0.075 mol) of potassium cyanate dissolved in 15 ml of water, the solvent is drawn off, the residue taken up in water and filtered. The precipitate which separates after acidification of the filtrate with hydrochloric acid, is filtered off with suction, washed with water and dried. There are obtained 8.0 g (45 percent of theory) of 4-([3-[5-methylisoxazolyl-(3)-carboxamido]-ethyl-benzene-sulphonyl-urea in the form ofa colorless powder of m.p. 201 C.

EXAMPLE 16 By analogy to Example 1 there are obtained from 5- methyl-isoxazole-3-carboxylic acid chloride and 4- aminomethylbenzene-sulphonamide hydrochloride, the compound 4-[5-methyl-isoxazolyl-(3)-carboxamide-methyl]-benzene-sulph0namide of m.p. 220 C., and therefrom with cyclohexyl-isocyanate, the compound N-(4-[5-methyl-isoxazolyl (3)-carboxamidomethyl]-benzene-sulphonyl)-N'-cyclohexy1-urea of m.p. 209 C.; with cycloheptylisocyanate, the com- EXAMPLE 17 By analogy to Example 1 there are obtained from 5- methyl-isoxazole-(3)-carboxylic acid chloride and 4- (-y-aminopropyl)-benzene-sulphonamide hydrochloride, the compound 4-(y-[5-methyl-isoxazolyl-( 3 )-carboxamido]-propyl)-benzene-sulphonamide of m.p. 171 C. and therefrom with cyclohexylisocyanate, the compound N-[4-(y-[5-methyl-isoxazolyl- (3)-carboxamido]-propyl)-benzene-sulphonyl]-N'- cyclohexyl-urea in the form of a colorless, finely crystalline powder ofm.p. 180 182 C.

EXAMPLE 18 By analogy to Example 1 there are obtained from 3,5-dimethyl-isoxazole-(4)-carboxylic acid chloride 4-(B-aminoethyl)-benzene-sulphonamide hydrochloride, the compound N-(B-[3,5-dimethylisoxazole-(4)-carboxamido]-ethy1)-benzene-sulphonamide of m.p. 173 C., and therefrom with cyclohexylisocyanate, the compound N-[4-(B-[3,5-dimethylisoxazole-(4)-carboxamido]-ethyl)-benzene-sulphonyl]-N'-cyclohexyl-urea of m.p. 167 C. in the form of a colorless, finely crystalline powder.

EXAMPLE 19 By analogy to Example 1 there are obtained from 3 ,4-tetramethylene-isoxazole-( 5 )-carboxylic acid chloride and 4-(B-aminoethyl)-benzene-sulphonamide hydrochloride, the compound 4-(B-[3,4- tetramethylene-isoxazole-( 5 )-carboxamido]-ethyl benzene-sulphonamide of m.p. 162 C., and therefrom with cyclohexyl-isocyanate, the compound N-[ 4-( B-[ 3 ,4-tetramethylene-isoxazole-( 5 )-carboxamido]-ethy1)-benzene-sulphonyl]-N'-cyclohexyl-urea of m.p. 143C. in the form of a colorless, finely crystalline powder.

EXAMPLE 20 By analogy to Example 1 there are obtained from 4,5-tetramethylene-isoxazole-(3)-carboxylic acid chloride and 4-(B-aminoethyl)-benzene-sulphonamide hydrochloride, the compound 4-(B-[4,5- tetramethylene-isoxazole-( 3 )-carboxamido]-ethyl)- benzene-sulphonamide of m.p. 175 C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(B- [4,5-tetramethylene-isoxazole-(3)-carboxamido]r ethyl)-benzene-sulphonyl]-N-cyclohexyl-urea of m.p. 153 C. in the form of a colorless, finely crystalline powder.

.pound EXAMPLE 21 By analogy to Example 1 there are obtained from 3,5-dimethyl-isoxazolyl-(4)-acetic acid chloride and 4- (B-aminoethyl)-benzene-sulphonamide hydrochloride, the compound 4-(B-[3,5-dimethyl-isoxazolyl-(4)- acetamido]-ethyl)-benzene-sulphonamide of m.p. 168 C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(B-[3,5-dimethyl-isoxazolyl-(4)- acetamido]-ethyl)-benzene-sulphonyl]-N-cyclohexylurea in the form of a colorless, finely crystalline powder ofm.p. 160-163 C.

EXAMPLE 22 By analogy to Example 1 there is obtained from methyl-isoxazole-3-carbonic acid chloride and 4-(13- aminopropyl)-benzene-sulphonamide hydrochloride the compound 4-(B-[5-methyl-isoxazoly1-(3)-carbonamido]-propyl)-benzene-sulphonamide of m.p. 174 C. and therefrom with cyclohexyl-isocyanate, the compound N-[4-(B-[5-methyl-isoxazoly1-(3)-carbonamido]-propyl)-benzene-sulphony1]-N -cyc1ohexyl-urea ofm.p. 158 C.

EXAMPLE 23 By analogy to Example 1 there is obtained from 5- methylisoxazole-3-carbonic acid chloride and 4-(aaminopropyl)-benzene-sulphonamide hydrochloride, the compound 4-(a-[S-methy1-isoxazo1yl-(3)-carbonamido1-propylbenzene-sulphonamide of m.p. 165

C., and therefrom with cyclohexyl-isocyanate, the compound N-[4-(a-[ 5-methyl-isoxazolyl-( 3 )-carbonamido]-propyl)-benzene-sulphonyl]-N'-cyclohexyl-urea of m.p. 185 C.

EXAMPLE 24 By analogy to Example 1, there is obtained from 1,5- dimethylpyrazolyl-(3)-carbonic acid chloride(prepared from the corresponding carbonic acid and thionyl chloride) and 4-(B-aminoethyl)- benzene-sulphonamide hydrochloride, the compound 4-([3-[ l ,5-dimethylpyrazolyl-(3 )-carboxamido]-ethyl)- benzene-sulphonamide and therefrom with cyclohexylisocyanate, the compound N-[4-(B-[ 1,5-dimethylpyrazolyl-93)-carboxamido]-ethyl)-benzene-sulphonyl]-N'-cyclohexyl-urea of m.p. 205 207 C.

EXAMPLE 25 By analogy to Example 1 there is obtained from 3- methylisothiazolyl-(S)-carbonic acid chloride and 4- (Baminoethyl)-benzenesulphonamide hydrochloride, the compound 4-(B-13-methylisothiazolyl-(5)-carboxamido]-ethyl)-benzene-sulphonamide of m.p. 190 C., and therefrom with cyclohexyl-isocyanate, the com- N-[4-( fl-[ 3 -m ethylisothiazolyl-( 5 )-carboxamido]-ethyl)-benzenesulphonyl]-N'-cyclohexyl-urea ofm.p. 176C.

EXAMPLE 26 By analogy to Example 1 there is obtained from 5- methylisoxazole-3-carbonic acid chloride and 3-(B- aminoethyl)-benzene-sulphonamide hydrochloride, the compound 3-(B-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)-benzene-sulphonamide of m.p. 155 C.,

Blood sugar in of starting values Hours after N-[4-(B-[5-methylisoxa- Adminiszolyl-( 3 )-carboxamido]- Tolbutamide tration ethyl)-benzenesulphonyl]- N -cyclohexyl urea Dosage mg/ g The toxicity of N-[4-(B-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)-benzenesulphonyl]-N-cyclohexyl urea is low, 2.8 g/kg of body weight being tolerated in the mouse in oral administration. For therapeutic purposes there is, for example, oral administration of N-[4- (B-[S-methylisoxazolyl]-( 3 )-carbox-amido]-ethyl)- benzenesulphonyl]-N'-cyclohexyl urea in tablets or capsules, for instance in dosages of l to 10 mg per person.

TABLETS The finely pulverized active agent is thoroughly mixed with the requisite additions and compressed into tablets so that each tablet contains the following substances:

1 mg N-[4-(B-[S-methylisoxa-zolyl-(3 )-carboxamido]-ethyl)-benzenesulphonyl]-N '-cyclo-hexyl urea 10 mg Colloidal silica 20 mg Cornstarch 1 mg Magnesium stearate 68 mg Lactose HARD GELATIN CAPSULES The finely pulverized active agent is mixed with the requisite additives and filled into capsulesso that each capsule contains the following substances:

1 mg N-[4-B-[5-methy1isoxa-zo1y1-(3)-carboxamido]-ethyl)-benzenesulphonyl]-N'-cyclo-hexyl urea 79 mg Lactose 10 mg Cornstarch The invention is defined by the appended claims, wherein the compounds set forth are representative only of the entire genus, all the compounds of which have essentially the same desirable properties and characteristics.

What is claimed is:

1. A compound of the formula:

l O R O g II l R CHzh-C-N-Y SOzNH-CN\ \O/ un wherein R is hydrogen or methyl;

each of R and R" when taken individually is hydrogen, halogen, alkyl of one to six carbon atoms, or phenyl; or R and R" when taken together are tetramethylene; R' and R"" i. when taken individually are a. hydrogen, b. alkyl of up to l2 carbon atoms,

c. phenyl, d. benzyl, e. phenethyl, f. a saturated alicyclic hydrocarbon unsubstituted or substituted by from one to three methyl groups and containing a total of from five to 12 carbon atoms, said alicyclic hydrocarbon being selected from the group consisting of monocycloalkyl, bicycloalkyl and tricycloalkyl;or methyl or ethyl substituted by said alicyclic hydrocarbon; or when taken together with the nitrogen atom to which they are attached, are an unsubstituted or methyl substituted member selected from the group consisting of pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methylpiperazine, 4,7-endocyclobutylene-(l',2')-octahydroisoindoH-yl, camphidino, 2-azabicyclo[2.2.2.]oct-2-yl and 3-azabicyclo[3.2.2. ]non-3-yl; Y is alkylene of one to eight carbon atoms; and n is a whole number between and 4.

2. An alkali metal or alkaline earth metal salt of a compound of claim 1.

3. The compound according to claim 1 which is N- [4-(B-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)- benzenesulphonyl]-N'-cyclohexyl urea.

4. The compound according to claim 1 which is N- [4-(B-[3-methyl-isoxazolyl-( 5 )-carboxamido]-ethyl benzene-sulphonyl]-N-cyclohexyl-urea.

5. The compound according to claim 1 which is N- [4-(fi-[3-methylisoxazolyl-( S )-carboxamido]-ethyl)- benzenecyclohexyl-methyl)-urea.

6. The compound according to claim 1 which is N- [4-(B-[3-methylisoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-( l-methyl-2,5-endomethylenecyclohexyl-methyl)-urea.

7. The compound according to claim 1 which is N- sulphonyl]-N-(2,5-endomethylene- I 16 [4-(B-[3-methylisoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-(4-methyl-cyclohexyl)-urea.

8. The compound according to claim 1 which is N- [4-(B-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-(4-methylcyclohexyl)-urea.

9. The compound according to claim 1 which is N- [4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-nortricyclyl-urea.

10. The compound according to claim 1 which is N- [4-(B-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl1-N'-(2,5-endomethylene-cyclohexyl-methylD-urea. I

11. T e compound according to claim 1 which 15 N- [4-(a-[3-methyl-isoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-cyclohexyl-urea.

12. The compound according to claim 1 which is N- [4-(a-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-cyclohexyl-urea.

13. The compound according to claim 1 which is N- [4-(fi-[5-methylisoxazolyl-(3)-carboxamido]-ethyl)- benzene-sulphonyl]-N-cyclopentyl-urea.

14. The compound according to claim 1 which is N- [4-(B-[3-methylisoxazolyl-(5 )-carboxamido]-ethyl)- benzene-sulphonyl]-N-cyclooctyl-urea.

15. The compound according to claim 1 which is N- [4-(B-[3-methylisoxazolyl-(5)-carboxamido]-ethyl)- benzene-sulphonyl]-N'-cycloheptyl-urea.

16. The compound according to claim 1 which is N- [4-(B-[5-methylisoxazolyl-(3 )-carboxamido]-ethyl)- benzene-sulphonamidocarbonyl1-4,7-endocyclobutylene-( l ,2 )-octahydro-isoindole.

17. The compound according to claim 1 which is N- [4-(B-[ 3 ,4-tetramethylene-isoxazole-( 5 )-carboxamido]-ethyl-benzene-sulphonyl]-N'-cyclohexyl-urea.

18. The compound according to claim 1 which is N- [4-(B-[4,5 -tetramethylene-isoxazole-( 3 )-carboxamido]-ethyl)-benzene-sulphonyl-N'-cyclohexyl-urea.

19. The compound according to claim 1 which is N- [3-(B-[5-methylisoxazolyl-( 3 )-carboxamido]-ethyl)- benzene-sulphonyl]-N-cycloheXyl-urea.

20. The compound according to claim 1 which is N- [4-(a-[5methylisoxazolyl-( 3 )-carboxamido]-ethyl)- benzene-sulphonyl]-N'-(4-methyl-cyclohexyl)-urea.

21. The compound according to claim 1 which is N- [4-(B- 5-methylisoxazolyl-( 3 )-carboxamido]-ethyl)- benzene-sulphonyl]-N'-cyclooctyl-urea.

22. The compound according to claim 1 which is N- [4-[5-methylisoxazolyl-(3)-carboxamido]-methylbenzene-sulphonyl]-N'-cyclohexyl-urea.

23. The compound according to claim 1 which is N- [4-(a-[5-methyl-isoxazolyl-(3)-carboxamido]-propyl)- benzene-sulphonyl]-N'-cyclohexyl-urea.

i I! k 

2. when taken together with the nitrogen atom to which they are attached, are an unsubstituted or methyl substituted member selected from the group consisting of pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methylpiperazine, 4,7-endocyclo- butylene-(1'',2'')-octahydroisoindol-1-y1, camphidino, 2-azabicyclo(2.2.2.)oct-2-y1 and 3-azabicyclo(3.2.2.)non-3-y1; Y is alkylene of one to eight carbon atoms; and n is a whole number between 0 and
 4. 2. An alkali metal or alkaline earth metal salt of a compound of claim
 1. 3. The compound according to claim 1 which is N-(4-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzenesulphonyl)-N''-cyclohexyl urea.
 4. The compound according to claim 1 which is N-(4-( Beta -(3-methyl-isoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 5. The compound according to claim 1 which is N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)-benzene- sulphonyl)-N''-(2,5-endomethylene-cyclohexyl-methyl)-urea.
 6. The compound according to claim 1 which is N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N''-(1-methyl-2,5-endomethylene-cyclohexyl-methyl)-urea.
 7. The compound according to claim 1 which is N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N''-(4-methyl-cyclohexyl)-urea.
 8. The compound according to claim 1 which is N-(4-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N''-(4 -methylcyclohexyl)-urea.
 9. The compound according to claim 1 which is N-(4-( Beta -(5-methyl-isoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -nortricyclyl-urea.
 10. The compound according to claim 1 which iS N-(4-( Beta -(5-methyl-isoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N''-(2,5 -endomethylene-cyclohexyl-methyl)-urea.
 11. The compound according to claim 1 which is N-(4-( Alpha -(3-methyl-isoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 12. The compound according to claim 1 which is N-(4-( Alpha -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 13. The compound according to claim 1 which is N-(4-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclopentyl-urea.
 14. The compound according to claim 1 which is N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclooctyl-urea.
 15. The compound according to claim 1 which is N-(4-( Beta -(3-methylisoxazolyl-(5)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cycloheptyl-urea.
 16. The compound according to claim 1 which is N-(4-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonamidocarbonyl) -4,7-endocyclobutylene-(1'',2'')-octahydro-isoindole.
 17. The compound according to claim 1 which is N-(4-( Beta -(3, 4-tetramethylene-isoxazole-(5)-carboxamido)-ethyl-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 18. The compound according to claim 1 which is N-(4-( Beta -(4, 5-tetramethylene-isoxazole-(3)-carboxamido)-ethyl)-benzene-sulphonyl-N'' -cyclohexyl-urea.
 19. The compound according to claim 1 which is N-(3-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 20. The compound according to claim 1 which is N-(4-( Alpha -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N''-(4-methyl-cyclohexyl)-urea.
 21. The compound according to claim 1 which is N-(4-( Beta -(5-methylisoxazolyl-(3)-carboxamido)-ethyl)-benzene-sulphonyl)-N'' -cyclooctyl-urea.
 22. The compound according to claim 1 which is N-(4-(5-methylisoxazolyl-(3)-carboxamido)-methyl-benzene-sulphonyl)-N'' -cyclohexyl-urea.
 23. The compound according to claim 1 which is N-(4-( Alpha -(5-methyl-isoxazolyl-(3)-carboxamido)-propyl)-benzene-sulphonyl)-N'' -cyclohexyl-urea. 